The Agilent software drivers from Varian are the connection between Varian dissolution testers and the Agilent 8453 Spectrophotometer. The drivers allow full control of the dissolution tester(s) (VK 7000, VK 7010, VK 7020S, VK 7025, or VK 7030), including sampling manifolds, in-vessel temperature measurement, and dosage delivery mechanism (ideal for staggered starts). They also enable control of the Agilent peristaltic pump, the Varian bi-directional pump, or the Varian syringe pump and filter changer. Use of the Varian peristaltic pump allows the back flushing of filters.
Both single- and multi-bath drivers are available. In a single bath configuration, eight flow cells (6 samples, standard and blank) are utilized, each with a dedicated line. Samples are taken simultaneously; then the lines are purged, returning the material to each vessel. The multi-bath system drivers can control up to 4 testers and pull each sample sequentially. Each dissolution bath utilizes a single flow cell. The standard, blank, and 6 samples are sequentially pumped into the flow cell, read, and discarded.A data report containing all test parameters is automatically generated at the conclusion of the test.
Optimize Communication Between Varian and Agilent Components
The V-series baths feature Auto Spindle Control (ASC). These electronic gear mechanisms allow each spindle to be operated independently. In addition, the V-series baths feature individually controlled sampling cannula. You control when each cannula is lowered into each vessel.
Auto Spindle Control
The V-series baths feature Auto Spindle Control (ASC). These electronic gear mechanisms allow each spindle to be operated independently. In addition, the V-series baths feature individually controlled sampling cannula. You control when each cannula is lowered into each vessel.
Why is This Important?
The USP suggests that dissolution media is non-rotating when dosage forms are delivered into the vessel. The USP requires that the dosage form be allowed to sink to the bottom of the vessel before rotation is started. The Varian software drivers when configured with the V-series tester and the ASC option make it possible to meet USP requirements by controlling each spindle individually. Rotation of each paddle begins after the dosage for the particular vessel is introduced, thus making automated staggered starts possible.At each time point you have the option of lowering all the sampling cannulas at once, or sequentially lowering the sampling cannula. You limit the hydrodynamic disturbance when only the appropriate cannula is in the media.
Sequential Automated Testing
The Agilent drivers enable compliance with USP guidelines by delivering dosage forms into non-rotating media. This is done sequentially by controlling the spindles individually. Here’s how it works:
