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Sample Preparation
Solid Phase Extraction (SPE)
Filtration
Flash Purification
Liquid/Liquid Extraction
Preparative HPLC Columns

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Liquid Liquid Extraction Applications

Isolation of compounds from synthesis mixtures presents a different set of challenges from analytical work. Varian offers complementary solutions to your purification needs:

Clinical - Toxicology
AppNote
Number
Product Application Title Literature Reference
M0032 Tox Elut Drugs of Abuse in Urine for Thin Layer Chromatography Screening. Contact your nearest Varian office for further information.
M0039 Chem Elut Capillary Gas Chromatographic Analysis of Alditol Acetates of Neutral and Amino Sugars in Bacterial Cell Walls. J. Chromatogr., 256:429-438 (1983).
M0068 Tox Elut Single Reagent Polarization Fluoroimmunoassay for Barbiturates in Urine. Clin. Chem., 30(11):1765-1769 (1984).
M0078 Chem Elut Simultaneous Determination of Amiodarone and Its Major Metabolite Desethylamiodarone in Plasma, Urine and Tissues by High-Performance Liquid Chromatography. J. Chromatogr., 273:379-392 (1983).
M0087 Chem Elut Liquid Chromatography with Fluorometric Detection of Unconjugated Estriol in Serum of Pregnant Women. Clin. Chim. Acta, 128:9-17 (1983).
M0214 Chem Elut Procedure for Quantitative Extraction of Aldosterone from Urine. Procedure developed by K.L. Nickel, Reference Lab, Newbury Park, CA.
M0221 Chem Elut An Improved Sample Extraction Procedure for the HPLC Assay of Prednisone and Prednisolone in Human Serum. Procedure developed by J.T. Stewart, et al., Biological Availability Group Studies, Univ. of GA.
M0222 Chem Elut Prostaglandins and their Metabolites for Radio-TLC or GC/MS Analysis. Procedure developed by C. Robinson, Dept. of Clinical Pharmacology, Royal Postgraduate Medical School, Hammersmith Hospital, London, England.
M0223 Chem Elut Rapid Extraction of Vanillylmandelic Acid (VMA) and Homovanillylic Acid (HVA) in Urine for Analysis by GC-Mass Spectrometry Procedure developed by D.H. Altmiller, et al., Oklahoma Children's Memorial Hospital and University of Oklahoma Health Sciences Center, OK.
M0224 Chem Elut Cortisol, Free, In Serum (11-Hydroxycorticosteroids) by Fluorescence Spectrophotometry. Procedure developed by P. Bondo, et al., South Bend Medical Foundation, IN.
M0225 Chem Elut Rapid Extraction of Neutral & Basic Drugs of Abuse in Urine for Analysis by GC. Contact your nearest Varian office for further information.
M0226 Tox Elut Rapid Extraction of Drugs of Abuse in Urine for Thin Layer Chromatography Screening. Contact your nearest Varian office for further information.
M0275 Chem Elut Rapid Extraction of Disopyramide (Norpace) and Metabolite (N-despropyl disopyramide), etc. Procedure developed by J.J. Thoma, et al., Research Chemistry Dept., South Bend Medical Foundation, IN.
M0276 Chem Elut Rapid Extraction of Theophylline in Serum or Plasma for HPLC Analysis. Procedure developed by D.W. Fretthold, Cuyahoga County Coroner's Office, Cleveland, OH.
M0277 Chem Elut Rapid Extraction of Antiarrhythmic Drugs in Serum or Plasma, for HPLC Analysis. Procedure developed by J.J. Thoma, et al., Research Chemistry Dept., South Bend Medical Foundation, IN.
M0278 Chem Elut Rapid Extraction of Drugs of Abuse in Urine for Analysis by GC. Contact your nearest Varian office for further information.
M0279 Chem Elut Rapid Extraction of Anticonvulsants in Serum or Plasma, for HPLC Analysis. Procedure developed by D. Fretthold, et al., Cuyahoga County Coroner's Office, Cleveland, OH.
M0280 Chem Elut Rapid Extraction of Acetaminophen (Tylenol) in Serum, Plasma, or Urine, for HPLC Analysis. Procedure developed by J.J. Thoma, et al., Research Chemistry Dept., South Bend Medical Foundation, IN.
M0281 Chem Elut Rapid Extraction of 1,25-Dihydroxy Vitamin D3 from Plasma. Contact your nearest Varian office for further information.
M0282 Chem Elut Rapid Extraction of 17-OH Corticosteroids from Urine for Analysis with Zimmermann Colorimetric Reagents. Contact your nearest Varian office for further information.
M0283 Chem Elut Rapid Extraction of Tricyclic Antidepressants and Metabolites in Serum or Plasma, for HPLC Analysis. Procedure developed by J.J. Thoma, Research Chemistry Dept., South Bend Medical Foundation, IN.
M0284 Chem Elut Rapid Extraction of Lidocaine in Serum or Plasma, for GLC Analysis. Procedure developed by J.J. Thoma, et al., Research Chemistry Dept., South Bend Medical Foundation, IN.
M0285 Chem Elut Rapid Extraction of Hypnotic Drugs in Serum or Plasma, for HPLC Analysis. Procedure developed by D. Fretthold, et al., Cuyahoga County Coroner's Office, Cleveland, OH.
M0321 Chem Elut Misonidazole (MISO)+, Desmethylmisonidazole (9963) (RO 9963). Contact your nearest Varian office for further information.
M0322 Chem Elut 5-Fluorouracil. Contact your nearest Varian office for further information.
M0323 Chem Elut DTIC. Contact your nearest Varian office for further information.
M0329 Chem Elut A Screening Method for Establishing Laxative Abuse. Clin. Chem., 27(6):914-917 (1981).
M0329 Tox Elut A Screening Method for Establishing Laxative Abuse. Clin. Chem., 27(6):914-917 (1981).
M0336 Chem Elut Rapid and Sensitive Gas Chromatographic Method for the Determination of Alfentanil and Sufentanil in Biological Samples. J. Chromatogr., 224:122-127 (1981).
M0337 Chem Elut Determination of Levamisole in Plasma and Animal Tissues by Gas Chromatography with Thermionic Specific Detection. J. Chromatogr., 224:25-32 (1981).
M0338 Chem Elut A Rapid and Sensitive HPLC-Fluorescence Method for the Determination of Ketanserin and its Major Metabolite in Biological Samples: Application to the Extensive Study of the Bioavailability and Dose Proportionality of the Drug in Man. Paper submitted at International Symposium on Quantitative Luminescence Spectrometry in Biomedical Sciences, Ghent, Sept. 1984.
M0349 Chem Elut Retention Indices and Dual Capillary Gas Chromatography for Rapid Identification of Sedative Hypnotic Drugs in Emergency Toxicology. J. Anal. Toxicol., 8:129-134 (1984).
M0358 Chem Elut Determination of Glyceryl Trinitrate in Human Plasma by Gas Chromatography-Negative Ion Chemical Ionization-Selected Ion Monitoring. J. Chromatogr., 229:327-336 (1982).
M0372 Chem Elut HPLC Analysis of Clenbuterol, a Beta-Adrenergic Drug, in Equine Urine. J. Chromatogr. Sci., 23:308-312 (1985).
M0400 Chem Elut An Improved Radioreceptor Assay for 1,25-Dihydroxyvitamin D in Human Plasma. Anal. Biochem., 116:211-222 (1981).
M0444 Chem Elut The Combined Use of High-Performance Liquid Chromatography and Radioimmunoassay for the Bioanalysis of Nicomorphine and its Metabolites. J. Pharm. & Biomed. Anal., 2(1):91-99 (1984).
M0476 Chem Elut High Performance Liquid Chromatographic Assay of 2-[2-methoxy-4-(methylsulfinyl) phenyl]-1H-imidazo-[4,5-c] pyridine hydrochloride, a Potent Cardiotonic Agent J. Chromatogr., 342:228-233 (1985).
M0479 Chem Elut Determination of Procainamide and N-Acetylprocainamide in Breast Milk and Serum using High-Performance Liquid Chromatography. Procedure developed by H. Kubo et al., School of Pharmaceutical Sciences, Kitasato University, 5-9-1, Shirokane, Minato-ku, Tokyo 108, Japan.
M0503 Chem Elut Modifications in the Alditol Acetate Method for Analysis of Muramic Acid and Other Neutral and Amino Sugars by Capillary Gas Chromatography-Mass Spectrometry J. Chromatogr., 347:109-120 (1985).
M0519 Chem Elut Determination of Etoposide in Biological Materials by High Performance Liquid Chromatography: Development of Automatic Sample Clean Up Procedure. Bunseki Kagaku, 35(3):225-229 (1986).
M0520 Chem Elut Determination of Disopyramide in Serum by High Performance Liquid Chromatography. Bunseki Kagaku, 35(3):256-258 (1986).
M0532 Chem Elut Detection of Digoxin, Digitoxin, Their Cardioactive Metabolites and Derivatives by High Performance Liquid Chromatography and High Performance Liquid Chromato J. Chromatogr., 377:221-231 (1986).
M0559 Chem Elut Metabolite Identification of Missile Fuel JP-10 by Gas Chromatography Mass Spectrometry. Biomed. Mass Spectrom., 12(5):228-229 (1985).
M0592 Chem Elut Quantitation of Deoxynivalenol and its Metabolite in Bovine Urine and Feces by Gas Chromatography with Electron-Capture Detection. J. Chromatogr., 378:226-231 (1986).
M0594 Chem Elut Rapid Screening Procedure for the Detection of Tricothecenes in Plasma and Urine. J. Chromatogr., 378:375-383 (1986).
M0622 Chem Elut Toxicological Determination of Opiates in Urine of Man: Possibilities and Limitations of a Combined Use of Immunological Methods and Capillary Gas Chromatogr Procedure developed by M. Van den Heede, et al., Dept. of Toxicology, State University of Ghent, Belgium.
M0623 Chem Elut Application of the Combined Use of Fused Silica Capillary Columns and NPD for the Toxicological Determination of Codeine and Ethylmorphine in a Human Overdose J. Anal. Toxicol., 7:113-115 (1983).
M0625 Tox Elut A Computerized Colour-Coded TLC System for the Identification of Unknown Compounds in Biological Fluids. Procedure developed by N. Ward, et al., National Poisons Unit, New Cross Hospital, London, U.K.
M0626 Chem Elut A Rapid and Sensitive Method for the Detection and Quantification of Tilidine and Its Two Main Metabolites in Human Biological Fluids. Procedure developed by J. Cordonnier, et al., Dept. of Toxicology, State Univ. of Ghent, Belgium.
M0627 Chem Elut Saliva - Concentrations of Tilidine and Its Metabolites in Man. Procedure developed by J. Cordonnier, et al., Laboratories of General Biochemistry and Physical Pharmacy, State University of Ghent, Belgium.
M0628 Chem Elut Detection of Tilidine, Nortilidine, and Bisnortilidine in Dried Bloodstains. Procedure developed by J. Cordonnier, et al., Dept. of Toxicology, State Univ. of Ghent, Belgium.
M0664 Tox Elut Experience with a Screening Method for Laxative Abuse. Human Toxicol., 2:385-389 (1983).
M0726 Chem Elut Combined Liquid Chromatography/Radioimmunoassay with Improved Specificity for Serum Digoxin. Clin. Chem., 31(8):1272-1277 (1985).
M0738 Tox Elut Cocaine Extraction. Procedure developed by T. Butler, Associated Pathology Lab, Las Vegas, NV.
M0762 Chem Elut Simultaneous Determination of Glyceryl Trinitrate and its Principal Metabolites, 1,2- and 1,3-Glyceryl Dinitrate, in Plasma by Gas Chromatography-Negative Ion Chemical Ionization -- Selected Ion Monitoring. J. Chromatogr., 239:277-286 (1982).
M0763 Chem Elut Microdetermination of Prostaglandins and Thromboxane B2 by Gas Chromatography using an Electron-Capture Detector. J. Chromatogr., 239:595-608 (1982).
M0901 Chem Elut Detection of Trace Levels of Thiodiglycol in Blood, Plasma and Urine using Gas Chromatography-Electron-Capture Negative-Ion Chemical Ionisation Mass Spectrometry. J. Chromatogr., 449:261-270 (1988).
M0914 Chem Elut High-Performance Liquid Chromatographic Determination of (R)- and (S)-Proxyphylline in Human Plasma. J. Chromatogr., 491:355-366 (1989).
M0918 Chem Elut Determination of ?-Methyldigoxin and its Metabolites by High-Performance Liquid Chromatography and Fluorescence Polarization Immunoassay. J. Chromatogr., 489:425-431 (1989).
M0995 Chem Elut Concentrations of Morphine and Codeine in Serum and Urine After Ingestion of Poppy Seeds. Clin. Chem., 33(6):806-808 (1987).
M1016 Chem Elut A Simple High-Performance Liquid Chromatographic Determination of Mexiletine in Human Plasma at Therapeutic Levels. Chromatographia, 21:41-43 (1986).
M1034 Chem Elut Gas Chromatography-Mass Spectrometry of some Prostanoids with New Derivatizing Agents. J. Chromatogr., 399:223-234 (1987).
M1063 Chem Elut Determination of 6B-Hydroxycortisol in Urine by High-Performance Liqiud Chromatography with Fluorescence Detection. J. Liq. Chromatogr., 6(11): 1977-1985 (1983).
M1180 Chem Elut Methodology for the Analysis of Benzimidazole Anthelmintics as Drug Residues in Animal Tissues. J. Assoc. Off. Anal. Chem., 73(1): 22-25 (1990).
M1235 Chem Elut Simultaneous Measurement of Prednisone, Prednisolone and 6B-Hydroxyprednisolone in Urine by High-Performance Liquid Chromatography using Dexamethasone as the Internal Standard. J. Chromatogr., Biomed. Applic., 493:421-423 (1989).
M1300 Chem Elut Detection and Quantitative Determination of 3-Nitropropionic Acid in Bovine Urine. Toxicol. Lett., 50:213-220 (1990).
M1537 Chem Elut High-Performance Liquid-Chromatographic Determination of (<R>)-and (<S>)-Proxphylline in Human Plasma. J. Chromatogr., Biomed. Applic., 83(2):355-366 (1989).
M1884 Chem Elut Rapid Isolation of Acidic and Basic Drugs from Human Tissues by Coupled Chem Elute Extraction Columns. International Analyst, 1(3);28-29 (1987)
M1885 Chem Elut Qualitative and Quantitative Analyses of Phenol, Phenyl Glucuronide and Phenyl Sulphate in Urine and Plasma by Gas Chromatography-Mass Spectrometry. J. Anal. Toxicol., 12(6);344-347 (1993)
M1887 Chem Elut Comprehensive Drug Screening In Urine Using Solid Phase Extraction and Combined TLC and GC/MS Identification. J. Anal. Toxicol., 15(2) 71-81 (1991)
M1888 Tox Elut A Simplified Thin-layer Chromatogrphic System for the Detection of Commonly Abused Basic Drugs. Ann. Clin. Biochem. 24(5); 508-510 (1987)
M2037 Chem Elut A Simplified Procedure for the Isolation, Characterization, and Identification of Weak Acid and Neutral Drugs from Whole Blood. J. Anal. Toxicol., 11:198-204 (1987)
M2059 Chem Elut Determination of Serum Mexiletine Concentrations and its Protein Binding by High-performance Liquid Chromatography. Byoin Yakugaku., 18(5);477-485 (1992)
M2134 Chem Elut High-performance Liquid-chromatographic Determination of Clenbuterol and Cimaterol Using Post-column Derivatization. J. Chromatogr., Biomed. Applic., 102(2);537-549 (1991)
M2173 Chem Elut Derivatization Procedure Suitable for HPLC Analysis of Clenbuterol. J. Chromatogr. Sci., 29(5);190-193 (1991)
M2180 Chem Elut Rapid Liquid-chromatographic Method for the Simultaneous Determination of Plasma Prednisone, Prednisolone and Cortisol (Hydrocortisone) in Paediatric Renal-transplant Cases. Clin. Chem., 37(5);643-646 (1991)
M2215 Chem Elut Methods for the Analysis of Thiodiglycol Sulphoxide, a Metabolite of Sulphur Mustard, in Urine Using Gas Chromatography-Mass Spectrometry. J. Chromatogr., 558(2); 393-404 (1991)
M2285 Chem Elut Determination of Minoxidil in Human Urine by High-Performance Liquid Chromatography Using Ultraviolet Absorbance Detection. Procedure developed by N.K. Hopkins, et al, The Upjohn Company, Kalamazoo, MI
M2304 Tox Elut Comparison of XAD-2 Resin and ToxElut Columns in Urine Drug-Abuse Testing by TLC. Clin. Chem., 29(6);1199 (1983)
M2308 Chem Elut Detection of Clenbuterol Residues in Treated Pigs. J. Food and Feed Chem., 17(1);1039-1041 (1992)
M2358 Chem Elut A New Partition Thin-Layer Chromatographic Method for Steroid Separations. Procedure developed By Joel L. Brind et al., Orentreich Foundation for the Advancementn of Science, New York, NY, USA.
M2388 Chem Elut A Method for the Simultaneous Determination of Cocaine, Benzoylecgonine, and Ecgonine Methyl Ester in Blood and Urine Using GC/EIMS with Derivatization to Produce High Mass Molecular Ions. J. Anal. Toxicol., 12 (September/October);(1988)
M2411 Chem Elut Simultaneous Analysis of Antiarrhythmic Drugs and Metabolites by High Performance Liquid Chromatography: Interference Studies and Comparisons with Other Methods. Clin. Biochem., 15(6);284-290 (1982)
M3121 Hydromatrix Chem Elut: Disposable extraction columns for the rapid extraction of 17-OH corticosteroids from urine Varian Germany Application
M3188 Hydromatrix Solid-phase extraction of Vitamine D3 (1,25-dihydroxy) from serum (Original language: german: Festphasenextraktion von Vitamin D3 /1,25-Dihydroxy) aus Serum) Varian Application Note

 



Environmental
AppNote
Number
Product Application Title Literature Reference
M0980 Chem Elut Rapid and Simple Method for Isolation and Gas Chromatographic Determination of N-Nitrosodimethylamine in Dimethyldithiocarbamate Formulations. J. Assoc. Off. Anal. Chem., 72(4):663-666 (1989).
M1231 Chem Elut Measurement of Ethyl Carbamate in Blood by Capillary Gas Chromatography/Mass Spectrometry Using Selected Ion Monitoring. Biomed. Environ. Mass Spectrom., 19:27-31 (1990).
M2305 Chem Elut Determination of Trisulfuron in Soil by Monoclonal Antibody-based Enzyme Immunoassay. J. Agric. Food Chem., 40(6);1093-1098 (1992)



Food & Beverages
AppNote
Number
Product Application Title Literature Reference
M0008 Chem Elut Milk Aflatoxin Extraction and Chromatography. Contact your nearest Varian office for further information.
M0010 Chem Elut Fate of Mycotoxins During Processing of Foodstuffs 11 - Deoxynivalenol (Vomitoxin) During Making of Egyptian Bread. J. Food Protection, 46(6):484-486 (1983).
M0011 Chem Elut Rapid Extraction of Patulin from Apple Juice for Analysis by HPLC. Contact your nearest Varian office for further information.
M0353 Chem Elut Choice of Methods for the Determination of Abscisic Acid in Plant Tissue. J. Chromatogr., 256:439-446 (1983).
M0379 Chem Elut Effects of Experimental Flour Milling and Breadbaking on Retention of Deoxynivalenol (Vomitoxin) in Hard Red Spring Wheat. Cereal Chem., 60(6):421-4 (1983).
M0593 Chem Elut Gas Chromatographic Analysis of Milk for Deoxynivalenol and its Metabolite DOM-1. J. Assoc. Off. Anal. Chem., 69(1):41-43 (1986).
M0599 Chem Elut Rapid and High Recovery Method for Aflatoxins in Food and Feed by SPE Cleaning. Procedure developed by G. Cirilli, et al., Applied Analytical Chemistry Laboratory, Bologna, Italy.
M0805 Hydromatrix Improved Method for Partition of Organophosphate Pesticide Residues on a Solid Phase Partition Column. J. Assoc. Off. Anal. Chem., 71(4):731-734 (1988).
M0964 Chem Elut Liquid Chromatographic Determination of Zearalenone and _- and ?-Zearalenols in Milk. J. Assoc. Off. Anal. Chem., 71(6):1176-1179 (1988).
M1236 Chem Elut Selective On-Column Extraction of Organochlorine Pesticide Residues from Milk. J. Chromatogr., 456:143-148 (1988).
M1238 Chem Elut Separation and Identification of Volatile and Non-Volatile Compounds of Wine by Sorbent Extraction and Capillary Gas Chromatography. J. High Res. Chromatogr., 13:352-355 (1990).
M1950 Hydromatrix Enhanced Supercritical Fluid Carbon Dioxide Extraction of Pesticides from Foods Using Pelletized Diatomaceous Earth. J. Assoc. Off. Anal. Chem., 74:661-666 (1991)
M2130 Chem Elut Determination of Pantothenic Acic in Infant Formulas by High Performance Liquid Chromatography. J. Japan Soc. Food Sci.Technol., 38(4);275-279 (1991)
M2283 Chem Elut Determination of Ethyl Carbamate in Alcoholic Beverages and Foods by Gas Chromatography with Mass Selective Detection: Collaborative Study. Procedure developed by Benjamin J. Canas, et al, Food and Drug Administration, Washington, D.C. 20204
M2612 Hydromatrix Rapid Solid-Phase Extraction Method for the Detection of Volatile Nitrosamines in Food J. Agric. Food Chem., 45:4706-4713 (1997)
M2750a Chem Elut Compounds of Wine by Sorbent Extraction and Capillary Gas-Chromatography Journal of High Resolution Chromatography, 13:352-355 (1990)